The Cabinet of the United States of Mexico is an executive council that serves at the pleasure of the President. Each member of the Cabinet is the Secretary of an executive department of the government.

When President Andrew Jackson first organized the government of the U.S.M. in 1821, the cabinet posts (and presumably departments) included the Secretary for Religions and the Secretary for Indian Affairs. When Jackson made his "grand tour" of the U.S.M. in 1823, he was accompanied by his Secretary of the Exchequer and Secretary of War, while the Secretary of State remained in Mexico City to administer the government in Jackson's absence. Jackson's Secretary of Agriculture, Homer Brown, gave an unconvincing speech at the 1843 Continentalist Party convention in Henrytown. In 1853, President Hector Niles ordered his Secretary of Home Affairs, Fidel Sonora, to carry out a survey of Mexico's resources in the wake of the Rocky Mountain War. In the 1902 Mexican elections, one of the candidates for President was Benito Hermión's Secretary for Postal Affairs, George Craig.

At the time of President George Vining's death in 1881, there were eleven Cabinet Secretaries.

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